18 years old male with bilateral weakness of lower limbs.
A 18 year old male with bilatera weakness of lower limb
I have been given this case to solve in an attempt to understand the topic of "patient clinical data analysis" to develop my competency in reading and comprehending clinical data including history ,clinical findings ,investigations and come with an diagnosis and treatment plan.
You can find entire real patient clinical data from the link here:https://hitesh116.blogspot.com/2020/05/12may-2020-elog-medicine-intern.html?m=1
Chief complaints :
1) weakness of both lower limbs since 20 days .
2) H/0 of difficulty in squatting position and waking up.
3) H/o of difficulty in wearing and holding chappals.
Explaination
Weakness initially started at proximal region and then progressed to distal region of lower limb.
On examination , areflexia present
It suggestive of LMN lesion.
Anatomical location ??
1) anterior horn cell
2) ganglion
3)spinal nerve root
4) plexus
5) peripheral nerve
6) neomuscular junction
7) muscle
The anatomical location is muscle as it is completely symmetrical, affecting predominantly lower limb, progressing from proximal to distal, no wasting and increase in creatine kinase levels.
- As weakness is persistent it is suggestive of myopathy.
Myopathies may be inherited or acquired
Inherited -
1) Duchenne muscular dystrophy
2) Becker's muscular dystrophy
Acquired-
1)Inflammatory myopathy - no signs of inflammation in this case
2) drug induced myopathy - no h/ o of drug inthis case
3) hypothyroidism induced myopathy- thyroid is normal in this case
The probable diagnosis inthis case is
Becker' s muscular dystrophy
- X - linked recessive
- onset of disease variable
- no mental retardation but in Duchenne muscular dystrophy there is mental retardation.
Treatment:
- symptomatic treatment only possible as there is no cure for Becker's disease.
1) steroids.
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